Comparison of Efficacy of Ciprofloxacin and Co-Trimoxazole in Escherichia Coli Urinary Tract Infection

Abstract

Objective: To compare the efficacy of ciprofloxacin and co-trimoxazole in urinary tract infection due to
Escherichia Coli.
Study Design: A cross- sectional study.
Place and Duration of Study: This study was conducted at the Department of Medicine, Muhammad Teaching
Hospital (MTH), Peshawar, Pakistan from 1 July 2022 to 31 December 2022.
Methods: Patients were randomly and consecutively assigned to either group by using lottery method (double
blind). A total of 194 patients diagnosed with urinary tract infection due to E coli were randomly divided into
two groups, 97 patients in each group, using 54% efficacy of ciprofloxacin, 74% efficacy of Co-Trimoxazole, 95%
confidence level, and 90% power of test, using WHO software. “Group-A' for Ciprofloxacin 500mg BD and
th 'Group-B' for Co-Trimoxazole 960mg BD. All the recruited patients were followed up after the 48 hour of their
treatment and results were recorded. The chi-Square test was applied to compare the efficacy results of both
drugs where a PValue < 0.05 was considered as significant value.
Results: The mean age of group A participants were 48.4 + 11.1 years, whereas, in group B it was 48.2 + 11.5
years. There were 69.1% males and 30.9% females in group A compared to 80.4% males and 19.6% females in
group B. After the 48 hour of end treatment, efficacy was 79.3% and 50.5%, in groups A and B respectively (p-value = 0.000).
Conclusion: As compared to Cotrimoxazole, Ciprofloxacin is more effective in treating E. coli-caused urinary
tract infections.

How to cite this: Ayaz M, Kausar SAZ, Alamgir M, Muhammad S, Khan FM, Ullah S. Comparison of Efficacy of Ciprofloxacin and CoTrimoxazole in Escherichia Coli Urinary Tract Infection. Life and Science. 2024; 5(2): 151-159. doi: http://doi.org/10.37185/LnS.1.1.595