Response of Capecitabine and Oxaliplatin Chemotherapy in Metastatic Colorectal Carcinoma

Abstract

Objective: To evaluate the frequency of objective response of Capecitabine and Oxaliplatin (CAPOX) in patients with metastatic colorectal cancer.
Study Design: A descriptive case study.
Place and Duration of Study: The Study was conducted at the Oncology Department, Hameed Lateef Hospital Lahore, Pakistan from 17^th July 2019 to 16^th January 2020.
Methods: A total of 80 participants aged 20-80 who were diagnosed with metastatic colorectal carcinoma were selected for the study. After baseline investigations and examination, all the patients were advised chemotherapy comprising oral capecitabine and oxaliplatin for 6 cycles. For assessment of the response, CT scans were done by the radiological department and reported after chemotherapy.
Results: 3 (3.8%) showed complete response, 32 (40%) showed partial response, 26 (32.5%) showed no response, and 19 (23.8%) patients showed disease progression after six cycles of chemotherapy. (43.8%) patients had objective responses, and 45 (56.2%) patients showed no objective response.
Conclusion: chemotherapy yields promising activity for treating metastatic colorectal cancer.

How to cite this: Rashid AA, Zafar A, Jafar A, Iqbal R, Siddiqi H, Ismail Z. Response of Capecitabine and Oxaliplatin Chemotherapy in Metastatic Colorectal Carcinoma. Life and Science. 2025; 6(1): 71-75. doi: http://doi.org/10.37185/LnS.1.1.528