Histopathological Study and Clinical Correlation of Glial Tumors at a Tertiary Care Hospital of Karachi

Abstract

Objective: To observe the spectrum of glial tumors in a resource-limited tertiary care setup of Karachi according
to the modified WHO central nervous system tumor classification.
Study Design:A retrospective analysis.
Place and Duration of Study: The study was conducted at the Oncology Ward of Jinnah Postgraduate Medical
Centre (JPMC), Karachi, Pakistan from August 2020 to January 2021.
Methods: The study was done to record data of patients diagnosed with glioma, which were registered during
2017 - 2019. Patients were classified according to recent WHO brain tumor classification. Data analysis as
performed by SPSS version 26.0.
Results: A total of 115 glioma cases were included. The most common presenting age group was in the 4th
decade of their life. Oligodendroglioma was the most common histological type 61
(53.5%). The most common presenting symptom was a headache in 46 (40%). The location of the tumor was
temporoparietal lobe in 51/115 (44.3%). Immunohistochemical studies showed a significant association with
histological subtypes (p-value: 0.002).
Conclusion: Oligodendroglioma was found to be the most common histological type. Immunohistochemical
marker GFAP expression was positive for the majority of diagnosed cases, where 1p19q / codeletion was
observed specifically in oligodendrogliomas.

How to cite this: Khan J, Bhatt IA, Jaffar N, Haider G, Zaman A, Shabbir SM Histopathological Study and Clinical Correlation of Glial Tumors: Tertiary Care Setting in Karachi. Life and Science. 2023; 4(4): 481-486. doi: http://doi.org/10.37185/LnS.1.1.337