The Emerging Role of microRNAs as Novel Diagnostic and Therapeutic Tools For Breast Cancer: a systematic review

Sara Mumtaz; Rida Fatima Saeed; Asma Saleem Qazi; Nosheen Akhtar; Uzma Azeem Awan

doi:10.37185/LnS.1.1.268

Sara Mumtaz National University of Medical Sciences, Rawalpindi, Pakistan
Rida Fatima Saeed National University of Medical Sciences, Rawalpindi, Pakistan
Asma Saleem Qazi National University of Medical Sciences, Rawalpindi, Pakistan
Nosheen Akhtar National University of Medical Sciences, Rawalpindi, Pakistan
Uzma Azeem Awan National University of Medical Sciences, Rawalpindi, Pakistan

DOI: https://doi.org/10.37185/LnS.1.1.268

Keywords: Breast Cancer, Diagnostics, miRNA, Molecular Biomarkers, Therapeutics

Abstract

Objective: A systematic review was conducted to evaluate recent studies performed on miRNAs as a diagnostic and therapeutic biomarker in breast cancer.
Study Design: Online standard databases like PubMed, EMBASE, Web of Science and COCHRANE library were searched to identify research articles relavant to the topic.
Place and Duration of Study: All online published studies between 2010-2020, in the scientific electronic databases were analyzed.
Materials and Methods: This review was performed according to PRISMA guidelines. Databases were systematically analyzed to explore the diagnostic and therapeutic potentials of miRNAs in breast cancer.
Results: We identified twenty-seven studies after literature search. We found six studies focused on diagnosis, sixteen on therapeutics and five on both diagnosis and therapeutics of miRNAs in breast cancer.
Conclusion: The combined data obtained in the present systematic review specify that miRNAs could serve as novel diagnostic and therapeutic biomarkers in breast cancer, whereas the practical relevance of the current results has yet to be established.