Chemical Constituents of Artemisia Annua are Potent Inhibitors of Alpha-Amylase in Type II Diabetes
Abstract
Objective: To identify the inhibitory effects of artemisinin and its derivatives against Alpha-Amylase in Diabetes
II.
Study Design: Insilico approaches using Bioinformatics techniques were used to access the effects of arteisinin
and its derivatives.
Place and Duration of Study: The study was conducted comprising 6 month period at Capital University of
Science and Technology, Islamabad, Pakistan.
Materials and Methods: In this work, the inhibitory effects of artemisinin and its derivatives were determined
by using in silico approach. For proper inhibitory effects, molecular docking and the pharmacokinetic
properties of the ligand were identified.
Results: Artemether was found to be the ligand that shows the best binding energy -7.08 Kcal/mol, strong
hydrogen bonding, 4 alkyl bonds, 0 bumps, inhibition constant 13.26, and better pharmacokinetic properties. It
has been selected as a lead compound as it is the most active compound for alpha-amylase inhibition.
Conclusion: In future, this work can be used in wet-lab analysis to confirm its adequacy and efficacy.
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